Diagnosis: Male factor infertility complicated by DH's Robertsonian Translocation 13;15.
IVF #1 July 2006 (Pensacola, FL) 23 eggs retrieved. 18 fertilized via ICSI. PGD. 8 "normal" embryos. Freeze all cycle due to severe OHSS. Hospitalized for 8 days.
FET #1 November 2006 (Pensacola, FL) Canceled at the last minute (after taking all the meds and shots for about 3 weeks) due to nonsuppression.
FET #2 September 2007 (Pensacola, FL) Transferred 1 female embryo. BFN.
FET #3 November 2007 (Pensacola, FL) Transferred 2 male embryos. BFN.
Decided to change fertlility clinics, so consulted with CCRM in Denver and SIRM in Las Vegas. Chose CCRM and transferred remaining 5 frozen embryos from Pensacola to Denver to have them genetically re-checked. 3 embryos died upon thaw, 1 embryo's genetic test came back inconclusive. 1 embryo normal for chromosomes 13 & 15. Re-froze the one normal embryo and the one inconclusive embryo.
One-day work up at CCRM in April 2008. FSH 7.18, E2 29, AMH 4.3, AFC 35+, genetic testing on me all came back normal. DH's genetic testing came back with 65% of sperm are affected with the unbalanced translocation.
IVF #2 July 2008 (Denver, CO) 30 eggs retrieved. 26 mature. 23 fertilized via ICSI. PGD. 7 embryos normal for chromosomes 13 & 15. 1 embryo made it to freeze. Transferred 2 grade AA blasts. BFN.
IVF #3 November 2008 (Denver, CO) 34 eggs retrieved. 25 mature. 22 fertilized via ICSI. 15 blasts for CGH testing. Results: 8 abnormal & 7 no results. The 7 no results will be thawed, re-biopsied, and re-vitrified; and the cells will be sent for FISH analysis for the translocation. Should get those results by Christmas. UPDATE: 1 blast is normal for 13 & 15 and 1 blast still no result.
FET #4 February 2009 (Denver, CO) Our first ever BFP!! Beta #1 (9dp5dt): 174 !!!!! Beta #2 (11dp5dt): 401 !!!!!
The embryologist called with an update on our 22 embryos. She said that all 22 embryos have divided and are excellent quality for the most part. She said that at this stage (Day 3), they'd like to see the cell number be between 6 - 10 cells. Seventeen embryos are within the 6 - 10 cells, with 11 embryos being at the perfect 8cells stage. Three embryos are at 4 cells. One embryo is at 3 cells, and one embryo is at 2 cells. She said that, on average, 40 - 50% of the embryos will go on and develop to the blast stage. We will get another update on Day 6 (Friday), after the biopsy and vitrification. I don't want to get my hopes up, but I'm somewhate relieved that the majority of the embryos are progressing nicely.
After the call from the embryologist, my nurse called to see how I'm doing. Yesterday, I wasn't feeling too well - very bloated and nauseous. We went in so that we could update our communicables, and I asked to see a nurse. After talking with the nurse, she wanted me to have an ultrasound and blood work done to check my CBC and electrolytes. The ultrasound showed a little bit of fluid in my ovaries and behind the uterus. I also was running a little bit of a fever (101 F). The nurse also weighed me, and I had gained 3 pounds since my physical. She said that wasn't bad, but for me to keep an eye on it. Yesterday after we got back to the hotel room, I weighed myself to get a baseline with the hotel scale. This morning, I weighed myself again and I had lost 5 pounds. But my stomach still feels bloated and distended. I will go in tomorrow for another ultrasound to see if there is more fluid build-up. Hopefully, I'm on my way to feeling better.
What I'm feeling now is no where nearly as bad as my 1st IVF in FL. OMG, it's like night and day. So the plan today is to rest and still drink lots of Gatorade.