Blood test results

While we were there in Denver, knowing that the cycle was going to be a freeze-all (due to the CGH testing), I wanted to make sure that all the i's are dotted and t's are crossed. I want to go into the FET (Frozen Embryo Transfer) knowing that we have done everything possible. I asked my nurse if there were any more tests that could be done on me and she mentioned that the only other thing that she could think of is the APA and Hypercoagular Panel. She said that the tests are costly, and they only recommend testing if a woman has had several miscarriages. I didn't want to take any chances, as it would be more costly doing another whole IVF/ICSI/CGH cycle than to have these tests done; so I asked her if I could go ahead and have those tests done. She said that she would talk with Dr. Schoolcraft about it, and he said that it'd be up to us. The APA is about $500 and the Hyper-Coag Panel is about $3000. What's another $3500 in the whole scheme of things, right? So two days before my ER, I had 10 vials of blood drawn (9 of them were for the tests and 1 vial was for my stim check hormone levels).

There may be a link between APA (Antiphospholipid antibodies) and implantation failures. APA have been postulated to bind to phospholipids on trophoblast tissue, impairing trophoblast development and preventing normal placentation. In other words, the presence of APA may prevent the embryo from implanting in the uterus. My APA test result came back as normal.

Hypercoagular Panel -
Most of my hypercoag panel came back as normal except for the Protein-S (free) and Plasminogen. My Protein-S level is low - mine is 54 and normal is 56 - 124. This means that I form clots easily (increased risk of thromboembolism). However, I have elevated Plasminogen levels, meaning that my body breaks up clots easily. It seems like one makes up for the other.

I was also tested for the MTHFR gene (hyperhomocysteinemia). I am heterozygous for the gene, meaning that I have one single copy of the gene (a1298c). The problem lies if there are two copies of the gene - causing the fetus to not get enough folate, leading to neural tube defect. But just as a precaution, I will be put on prescription Folic Acid (Folgard 2.2 mg).

My nurse said that she will call me after she talks with Dr. Schoolcraft about these results and see what he recommends. She said that my Protein-S is just two points away from normal, so he might just put me on baby aspirin or some other blood thinner.

While I had her on the phone, I asked her about how many days I would have to stay in Denver for the FET. She said that I could fly in the night before the embryo transfer and then leave two days later. And that my beta would be 9 days after the transfer. I told her that I probably would just stay in Denver until after the beta, so that I would know before coming back home. I would feel more at ease if I was not on the road during my wait.

I just want this to work. PLEASE PLEASE PLEASE!!


Dorrian said...

Linda, I'm glad ya'll are home safe and sound. I have been praying that this time it works. It seems like it's just not fair for you guys. I read your blogs and I cry with you. These are the reasons sometimes I question just what the good Lord has in plan for us. I'll continue to say prayers and think of you and Jerry!

Nikki said...

Hey Linda,

I am heterozygous for MTHFR as well, and my RE also said it was a "soft call" but put me on Folgard 2.2 mg. CCRM however doubled that dose for me.

My RE also said I could choose to be on Lovenox injections after a BFP - and I did choose to take the shots. I started with my last BFP, but that ended in an ectopic (long different story)

I hope your FET works - keeping my fingers crossed for you!

BTW - I tagged you for an award on my blog!

the Babychaser: said...

I'm so hoping your FET works. I know how long that 2ww can be when you're hoping against all hope!

(After reading your earlier post I felt exactly the same. "Infertility fatigue" has infected my family and friends as well. I think they just can't understand that it doesn't stop hurting, just because I'm not in a cycle right now or coming off of some bad news. They're just tired of me being sad, so they don't want to even think about it.)

Good luck in Denver!

Lisa said...

I'm praying and hoping right along with you!!!! It'll be here before you know it!

retro girl said...

I didn't know anything about this additional testing - thanks for the info. Best of luck on the FET. I think that's a great decision to stay out there (if you can) until the beta...less additional factors to cause stress.

Barb said...

Hi Linda!

Thanks for stopping by my blog! Are we looking at another Filipino family in Florida? That's a lot of alliteration and I like it. haha.

Anyway, lots of best wishes for success! I've been wishing a lot lately myself. :)

Lisa said...

I was just thinking! January is so long to wait before you hear anything. But at least you can totally enjoy the holidays -- not taking any needles or drugs. And you can even enjoy a drink to two! It'll be so nice to enjoy the holidays and then, in the new year, have those embryos come home!!! I know the waiting will be so hard, but just think, you have so many frozen normals. You are going to be a mom for sure!

DAVs said...

Thanks so much for your support. It means a lot.
I'm hoping for only the best for you--I really hope you get loads and loads of normal embies from which to choose and try!

Polly Gamwich said...

I think it was wise of you to do the panel. Seriously, how angry would you be if you did get pg and only end up m/c'ing b/c of something you could have done, if only you'd known. I get it.

I always recommend that ladies do it if they can.

Overall, you got some good results, so that's encouraging!

Happy Thanksgiving!