Diagnosis: Male factor infertility complicated by DH's Robertsonian Translocation 13;15.
IVF #1 July 2006 (Pensacola, FL) 23 eggs retrieved. 18 fertilized via ICSI. PGD. 8 "normal" embryos. Freeze all cycle due to severe OHSS. Hospitalized for 8 days.
FET #1 November 2006 (Pensacola, FL) Canceled at the last minute (after taking all the meds and shots for about 3 weeks) due to nonsuppression.
FET #2 September 2007 (Pensacola, FL) Transferred 1 female embryo. BFN.
FET #3 November 2007 (Pensacola, FL) Transferred 2 male embryos. BFN.
Decided to change fertlility clinics, so consulted with CCRM in Denver and SIRM in Las Vegas. Chose CCRM and transferred remaining 5 frozen embryos from Pensacola to Denver to have them genetically re-checked. 3 embryos died upon thaw, 1 embryo's genetic test came back inconclusive. 1 embryo normal for chromosomes 13 & 15. Re-froze the one normal embryo and the one inconclusive embryo.
One-day work up at CCRM in April 2008. FSH 7.18, E2 29, AMH 4.3, AFC 35+, genetic testing on me all came back normal. DH's genetic testing came back with 65% of sperm are affected with the unbalanced translocation.
IVF #2 July 2008 (Denver, CO) 30 eggs retrieved. 26 mature. 23 fertilized via ICSI. PGD. 7 embryos normal for chromosomes 13 & 15. 1 embryo made it to freeze. Transferred 2 grade AA blasts. BFN.
IVF #3 November 2008 (Denver, CO) 34 eggs retrieved. 25 mature. 22 fertilized via ICSI. 15 blasts for CGH testing. Results: 8 abnormal & 7 no results. The 7 no results will be thawed, re-biopsied, and re-vitrified; and the cells will be sent for FISH analysis for the translocation. Should get those results by Christmas. UPDATE: 1 blast is normal for 13 & 15 and 1 blast still no result.
FET #4 February 2009 (Denver, CO) Our first ever BFP!! Beta #1 (9dp5dt): 174 !!!!! Beta #2 (11dp5dt): 401 !!!!!
This morning, I had my first stim shot (1amp Menopur)..Tonight, Follistim. We went through our regular ritual of getting ready for the shot. I didn't feel the prick of the needle, but I did feel the sting of the medicine half-way through. Afterward, I gave my ovaries a pep talk. Grow follies grow! I know it's silly, but I've been trying to will my ovaries to produce between 30 - 35 quality eggs. I need that much, especially with the translocation issue.
At my suppression check yesterday (after taking 25 days of BCPs), the ultrasound tech counted a few small follicles. On my right ovary, there were 9 measureable follicles ranging in sizes from 2.6mm to 5.8mm. And on my left ovary, there were 8 measureable follicles ranging in sizes from 3.6mm to 9.1mm. That's 17 follicles total. I didn't think that I would have any measureable follicles, as I just came off of BCPs. So, I asked my IVF nurse about my ultrasound and all the follicles, and she said that seems about right, as my antral follicle count (AFC) is around 35. And she said that my hormone levels were right where I'm supposed to be at this stage.
After taking my first stim shot, I swear I could feel something cookin' in my ovaries. I don't know if it's all in my mind or not. I'm just hoping and praying that I develop a lot of good, quality eggs. I guess I'll be worried about it until my first stim check this Sunday in Denver.
We're leaving tomorrow morning, right after my morning shot. Next update will probably be Sunday. Keep us in your prayers!